Methylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

Comparing PET metabolic parameters with clinicopathological factors in predicting onset of early recurrence in recently diagnosed hepatocellular carcinoma

Introduction: Early recurrence of hepatocellular carcinoma (HCC) is a major risk factor affecting survival even after hepatectomy. Many clinical, biochemical parameters and pathological grading like fibrosis 1 index have been used for risk stratifying HCC. However not many studies have combined all of them. It is therefore important to risk stratify HCC especially with newer PE...

Hepatocellular carcinoma: a clinicopathological study.

OBJECTIVE To describe the clinico-pathological and radiological profile of hepatocellular carcinoma. STUDY DESIGN A case series. PLACE AND DURATION OF STUDY Medical Unit-III Ward-7, Jinnah Postgraduate Medical Centre, Karachi, from January to December 2008. METHODOLOGY All consecutive patients suspected of having hepatocellular carcinoma (HCC), were admitted and included in this study. Di...

Clinicopathological characteristics of hepatocellular carcinoma in Turkey.

BACKGROUND Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very common and highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factors in Turkey. MATERIALS AND METHODS In this study, patients who were diagnosed as suffering from HCC in the period between August 2004 and December 2011 were evaluated retrospectively. R...

Hepatocellular Carcinoma in Sheep